Use of strict criteria to evaluate MRI scans showed that in general, the spinal cord and associated structures do end closer to the tail in this breed compared to other breeds of similar size. The CHF-funded research team first set out to accurately define the anatomic changes common in Cavalier King Charles Spaniels. In humans and dogs, studies have demonstrated an association between SM and structures that anchor the bottom or caudal end of the spinal cord within the vertebral canal. These cavities can damage the spinal cord and result in clinical signs of pain and abnormal sensations. This changes the flow of fluid surrounding the brain and spinal cord (cerebrospinal fluid) and contributes to the formation of fluid-filled cavities within the spinal cord known as syringomyelia (SM). Results will help define the disorder and provide veterinarians and breeders with valuable information to identify and care for affected dogs and breed away from this painful condition.Ĭhiari-like malformation (CM) is a boney malformation seen in all Cavalier King Charles Spaniels where the skull is too small for the brain. With funding from the AKC Canine Health Foundation (CHF) ( Grant 02162-MOU: Defining the Genetic Foundations of Chiari-Like Malformation and Syringomyelia as a Tool to Better Treat Neuropathic Pain in the Dog), investigators at North Carolina State University completed an extensive study of the anatomic and genetic characteristics of this disorder and how they relate to clinical signs. The disorder is complex, and study is difficult because not all dogs with anatomic abnormalities show clinical signs and there are some dogs that exhibit severe signs but have no malformations. Several central nervous system malformations are seen in Cavalier King Charles Spaniels which cause symptoms of pain and abnormal sensations such as tingling or numbness.
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